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A new breakthrough in microfluidics could lead to autonomous blood analysis chips that will be able to diagnose diseases in mere minutes.
The device, referred to as SIMBAS, was developed by a team of researchers from Dublin City Univerisity in Ireland, Universidad de Valparaiso Chile, and the Bay area's own University of California, Berkeley. 'SIMBAS' stands for 'Self-powered Integrated Microfluidic Blood Analysis System', and needs no additional tubing in order to diagnose diseases.
The lack of additional components is specifically important, as it helps maintain the chip "tiny, portable, and inexpensive," according to UC Berkeley post-doctoral researcher in bioengineering, Ivan Dimov. "The dream of a true lab-on-a-chip has been around for awhile, but most systems developed therefore far have not been genuinely autonomous."
[Image: UC Berkeley]The chips will eventually be able to be utilised by workers in the field to diagnose diseases such as HIV and tuberculosis in a matter of minutes. The biochip is made of plastic and attributes five "inlets" on which the blood is dropped. The heavier red blood and white blood cells settle to the bottom of the trenches, and the blood moves by way of the chip in a "degas-driven" flow:
"For degas-driven flow, air molecules inside the porous polymeric device are removed by placing the device in a vacuum-sealed package. When the seal is broken, the device is brought to atmospheric conditions, and air molecules are reabsorbed into the device material. This generates a pressure distinction, which drives the blood fluid flow in the chip."
According to the researchers, they had been able to capture much more than 99 percent of the blood cells by separating the blood from plasma making use of this method. The team demonstrated its chip's capacity by placing a five-microliter sample of blood on the chip's inlets and receiving a read out of biotin levels in just 10 minutes.http://www.bestlaptopbattery.co.uk/hp/pavilion-dv2000.htm
"Envision if you had some thing as low-cost and as easy to use as a pregnancy test, but that could quickly diagnose HIV and TB," said UC Berkeley grad student Benjamin Ross.
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